Biofilm – what it is and why it matters

Feb 23, 2024

Biofilm refers to communities of bacteria that form in various environments, including the human body. These bacterial clusters, if left unchecked, undergo maturation, leading to the development of pathogenic bacterial complexes that can result in oral health issues such as dental caries, gingivitis, and periodontitis. Identifying, disrupting, and managing these biofilms is crucial for the success of treatments and the overall well-being of patients. The significance of addressing biofilms lies in their connection to oral health, which is often considered a vital aspect of overall well-being. Poor dental health not only serves as the root cause of various oral problems and systemic diseases but can also have negative psychological effects, impacting self-esteem. Despite ongoing efforts to prevent biofilm formation on dental enamel, the challenge persists due to the universal phenomenon of adsorption and adhesion by sessile cells on dental tissue. Therefore, rapid diagnosis, vigilant surveillance, and regular interventions are essential to effectively combat the consequences of biofilm formation and promote optimal oral health.

Read: Biofilm Clinical Article

Dental biofilm: Risks, diagnostics, and management by Rina Rani Ray

Excerpts from the clinical article:

Biofilms are communities of bacteria that exist in both the human body and the environment. If left unattended, these biofilms undergo maturation, and the resulting pathogenic bacterial complex can lead to dental caries, gingivitis, and periodontitis. It is important to identify, disrupt, and manage these biofilms to ensure the success of your treatments and the well-being of your patients.


Oral health is considered to be wealth, as poor dental health is not only the root cause of various oral problems and various systemic diseases but also imparts negative psychological effects by damaging self-esteem. Despite many promising strategies for the prevention of biofilm formation on dental enamel, the pervasive phenomenon of adsorption and adhesion by the sessile cells on dental tissue is becoming a universal phenomenon. Rapid diagnosis with strong surveillance and regular use of…

Watch: Does Dental Affect Your Heart

Does Dental Health Affect Your Heart? – Cleveland Clinic

To learn more about oral health and the risk for cardiovascular disease.

Read: Biofilm Clinical Article

Dental plaque as a biofilm and a microbial community – implications for health and disease – Philip D. Marsh

Excerpt from the clinical article:

Dental plaque is the community of microorganisms found on a tooth surface as a biofilm, embedded in a matrix of polymers of host and bacterial origin. Of clinical relevance is the fact that biofilms are less susceptible to antimicrobial agents, while microbial communities can display enhanced pathogenicity(pathogenic synergism). The structure of the plaque biofilm might restrict the penetration of antimicrobial agents, while bacteria growing on a surface grows slowly and display a novel phenotype, one consequence of which is a reduced sensitivity to inhibitors.


The key to a more complete understanding of the role of microorganisms in dental diseases such as caries may depend on a paradigm shift away from concepts that have evolved from studies of classical medical infections with a simple and specific (e.g. single species) etiology to an appreciation of ecological principles. The development of plaque-mediated disease at a site may be viewed as a breakdown of the homeostatic mechanisms that normally maintain a beneficial relationship between the resident oral microflora and the host. … This way, the clinician does not just treat the end result of the caries process but also attempts to identify and interfere with the factors that, if left unaltered, will inevitably lead to more disease.

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